Theresa May is to promise extra investment for the aerospace industry just days after Airbus threatened to reduce its UK presence because of Brexit disruption.
The Prime Minister will also say that her Brexit plan will secure millions of aviation jobs in Britain.
It comes amid growing criticism of her plan from MPs, with another government member resigning in protest on Sunday.
The proposal urges close links with the EU on trade in goods, but not services.
At a speech at the Farnborough Airshow on Monday, she will offer more than £300m of government money for several projects, including research on more environmentally-friendly aircraft.
There will be additional money for two new spaceports – one in Cornwall, one in Scotland – and a long-awaited commitment to build a new high-tech fighter aircraft that will eventually replace the Eurofighter Typhoon.
However, industry trade association ADS has warned the sector could be paralysed if Britain leaves the EU Customs Union and Single Market, given its dependence on cross-border trade in components.
In June, Airbus UK boss Tom Enders said it could pull production out of the UK if it quit the bloc without a transition deal. The French firm employs about 14,000 people in Britain.
However, last week Mr Enders tentatively welcomed Mrs May’s plan, saying the government is now moving in the right direction.
But in an interview with the BBC, the boss of Airbus’s arch rival, Boeing, pledged to keep investing in Britain.
Dennis Muilenberg said while the company did not welcome disruption to the movement of goods – or to the Europe-wide systems of aviation regulation – his company’s plans would not be changed by Britain’s plans to leave the EU.
In her speech, Mrs May will argue that her proposals – including frictionless free trade in goods and the avoidance of a hard border in Northern Ireland – will protect the supply chains big aerospace firms depend on.
She will also set out how the UK could remain part of EU agencies critical for the aerospace industry, such as the European Aviation Safety Agency.
“By working closely together, government and industry have ensured we remain at the forefront of civil aviation and that our air power is second to none,” she will say.
“Today I want us to build on that, and ensure not only that we retain our prominence, but that in an increasingly competitive industry we make the most of the opportunities that lie ahead.”
ADS has welcomed the government’s plan but insists there are important and complex issues still to be resolved.
However, chief executive Paul Everitt said the Prime Minister’s remarks were a “strong statement of intent” that would help build confidence and encourage investment.
“The international political, military and business leaders visiting Farnborough will be reassured by last week’s Brexit White Paper and are keen to hear more about the UK’s post-Brexit ambitions.”